Creating Cajun Cream Cheese Chicken Pasta Bake is a breeze when you follow these simple steps:

1. Preheat Oven: Preheat your oven to 350°F (175°C).
2. Cook Pasta: In a large pot of salted boiling water, cook the penne pasta according to package instructions until al dente. Drain and set aside.
3. Combine Chicken and Cream Cheese: In a mixing bowl, combine the shredded chicken and softened cream cheese. Mix until smooth and creamy.
4. Add Remaining Ingredients: Stir in the chicken broth, shredded cheddar cheese, diced tomatoes, Cajun seasoning, garlic powder, onion powder, salt, and black pepper until fully incorporated.
5. Mix in Pasta: Fold in the cooked penne pasta until all ingredients are well combined.
6. Transfer to Baking Dish: Pour the mixture into a greased 9×13-inch baking dish, spreading it evenly.
7. Bake: Place the dish in the preheated oven and bake for 25-30 minutes until bubbly and golden on top.
8. Garnish: Remove from the oven and let it cool for a few minutes before serving. Garnish with chopped green onions for a fresh touch.

By following these steps, you can easily create a delicious Cajun Cream Cheese Chicken Pasta Bake that will impress everyone at the dinner table.